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Registered: 05-2005
Posts: 816
Karma: 8 (+9/-1)
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Lasik damages every eye, people are still uninformed


With all of the current research clearly demonstrating permanent eye
damage
from refractive
surgery it is amazing anyone would let an animal have this surgery, let

alone a loved one.


Patients aren't really in a position to make an informed decision
because
they are not given all the information
they would require. The doctors would just as soon that patients do not
know
that a flap that never heals , induced
corneal distortions and permanent nerve damage are part of the package.


They don't explain how creation of the LASIK flap, the uneven nature of
the
lasering and the unpredictable ways
a flap can heal all contribute to higher order aberrations (distortions
in
the cornea that can't be corrected with glasses).


Best case scenario, LASIK is trading in your high quality correctable
vision
with glasses or contacts to lower quality vision without glasses...
with
accompanying corneal nerve damage, some extra aberrations, loss of
contrast
sensitivity in dim light and increased risk of accidental eye damage
and
ectasia for life.
8/25/2006, 7:56 am Link to this post Send Email to Myope5   Send PM to Myope5
 
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Re: Lasik damages every eye, people are still uninformed


New studies show LASIK damage to the eye at 100%.:
Excerpts from full text:

Permanent haze at the flap margin, 100% rate of interface particles,
100%
rate of Bowman's microfolds, 100% permanent interface scar "permanently


altered from normal", 100% epithelial thickening, acutely and
chronically
reduced keratocytes, some corneas had "empty spaces" in the interface
wound
"filled with foreign material suspicious for plastic particles",
necrotic
epithelial cells in the interface, chronically vacuolated keratocytes
in the
interface, corneal nerves MIA, and the flap does not fit to the
underlying
stroma.


Here's the abstract:


Ophthalmology. 2005 Apr;112(4):634-44.


Ex vivo confocal microscopy of human LASIK corneas with histologic and
ultrastructural correlation.


Dawson DG, Holley GP, Geroski DH, Waring GO 3rd, Grossniklaus HE,
Edelhauser
HF.


Department of Ophthalmology, Emory University School of Medicine,
Atlanta,
Georgia, USA.


OBJECTIVE: To perform confocal microscopy on postmortem human LASIK
corneas
and correlate these findings to histologic and ultrastructure
evaluations.
DESIGN: Prospective, consecutive, observational case series.
PARTICIPANTS:
Ninety postmortem LASIK corneas (47 patients) were evaluated for
histopathology, of which 22 consecutive corneas (12 patients) were also


evaluated by confocal microscopy. Six normal corneas (3 patients)
served as
controls. METHODS: This observational case series involving 22 corneas
from
12 patients with postoperative intervals from 1 month to 6.5 years
after
LASIK surgery were collected. The corneas were mounted in an artificial


anterior chamber and perfused with balanced salt solution before
confocal
microscopy was performed on the center of the cornea. The corneas were
then
bisected and processed for light and transmission electron microscopy.
RESULTS: Confocal microscopy, along with histologic and ultrastructural


correlations, demonstrated that the most prevalent alterations in the
centers of LASIK corneas were a slightly thickened epithelium caused by


focal basal epithelial cell hypertrophic modifications, random
undulations
in Bowman's layer over the flap surface, and a variably thick
hypocellular
primitive stromal interface scar. By using confocal microscopy, the
interface wound was easily identified in 100% of the cases because
numerous
brightly reflective interface particles were always present in the
hypocellular primitive stromal scar. These particles were found
primarily to
consist of organic cellular constituents, some of which were transient
in
nature. CONCLUSION: After LASIK, active stromal wound healing in the
central
cornea results in the production of a hypocellular primitive stromal
scar,
whereas secondary tissue adjustments seem to cause the Bowman's layer
undulations and the subsequent epithelial cell modifications. Most of
the
interface particles revealed by confocal microscopy in the region of
the
stromal scar are organic in nature and presumably innocuous to the
cornea.
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Re: Lasik damages every eye, people are still uninformed


Cornea
Volume 24(1) January 2005 pp 92-102

Pathologic Findings in Postmortem Corneas After Successful Laser In
Situ
Keratomileusis


Kramer, Theresa R MD, MBA; Chuckpaiwong, Varintorn MD; Dawson, Daniel G
MD;
L'Hernault, Nancy; Grossniklaus, Hans E MD; Edelhauser, Henry F PHD


>From the Emory Eye Center, Emory University, Atlanta, GA.


Received for publication February 23, 2004

Excerpts from text:


Pathologic Findings
Gross examination of the corneas was notable for hazy areas of scarring
at
the wound margin of the LASIK flap in 95% of corneas.


On light microscopy, the corneal stroma in or adjacent to the lamellar
wound
was marked by several pathologic changes including eosinophilic
deposits,
PAS-positive
extracellular matrix material, and varying numbers and types of
keratocytes,
while on TEM, electron-dense granular material, activated keratocytes,
and
quiescent keratocytes with small ([sign in to see URL] [mu]m diameter)
intracytoplasmic
vacuoles were detected in the same regions. Eosinophilic deposits were
found
in the wound in 43 of 43 corneas, and PAS-positive material was found
in the
wound in 43 of 43 corneas (Fig. 3A and B). On TEM, deposits of
electron-dense granular material interspersed with randomly ordered
collagen
fibrils were seen in the
lamellar wound and adjacent to keratocytes (Fig. 4A,B). Activated
keratocytes (ie, prominent rough endoplasmic reticulum, mitochondria,
golgi,
and electron dense material filled vesicles) were present in or
adjacent to
the wound in 4 of 33 corneas (Fig. 5A). Vacuolated keratocytes with
small
variably sized vacuoles were present in or adjacent to the wound in 32
of 33
corneas. The abundance and size of the vacuolations in the keratocytes
correlated slightly
with the length of postoperative period, with grading levels 2 and 3
being
more common in the early postoperative period. Additionally, in all
cases in
which electron-dense granular material was particularly abundant, an
activated or a quiescent keratocyte was located in the immediate area.
Intracytoplasmic stress fiber bundles in keratocytes suggestive of
myofibroblast differentiation were identified in only one cornea at the


wound margin. Further immunohistochemical analysis is underway to
positively
identify and locate keratocytes with myofibroblastic differentiation.
In one
cornea, extracellular vacuoles were identified in the stroma .


Debbie said:


I think it is hideous that so many LASIK patients report that their
vision
is not as crisp after LASIK, yet doctors do not warn patients up front
that
their visual quality after LASIK may be lower than with glasses. Since
this
is the visual quality you will have for the rest of your life, this
seems
like an important tidbit of information, no? By the way, my vision is
not merely less crisp, it is total garbage.


A study presented in the Review of Optometry [6] summarized surgical
(as
opposed to optical) complication rates following Lasik as follows:


Interoperative Flap Complications - 2.7%


Postoperative Flap Complications - 4.0%


Epithelial Ingrowth (Farah) - 14.7%


Epithelial Ingrowth (Wilson) - 4.3%


Epithelial Defects - 5.0%


Interface Debris - 6.8%


Flap Wrinkles - 5.9%

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